Gum Disease Bacteria Found in Alzheimer's Brains

Gum Disease Bacteria Found in Alzheimer's Brains

"Now, for the first time, we have solid evidence connecting the intracellular, Gram-negative pathogen, P. gingivalis, and Alzheimer's pathogenesis".

Professor Colin Masters AO from the Florey Institute said, "The blood test accurately predicted when members of a family with inherited Alzheimer's disease would begin to show symptoms". Most scientists think it is likely to be down to a combination of factors, including your genes and lifestyle.

Still, Edelmayer says with so much still unknown about the disease, studies like this are important for gaining a better understanding of Alzheimer's.

"We know diseases like Alzheimer's are complex and have several different causes, but strong genetic evidence indicates that factors other than bacterial infections are central to the development of Alzheimer's, so these new findings need to be taken in the context of this existing research", he argued.

In addition to the Porphyromonas gingivalis, the researchers found toxic enzymes produced by the bacteria called gingipains in the neurons of patients with Alzheimer's.

Singhrao, who has also conducted research into the cause of Alzheimer's, had earlier discovered that the bacteria invade the brains of mice which had gum infections.

The research, a five-year-long study with more than 150 patients in clinical trials, has successfully identified the blood brain barrier as the root of the disease, which affects an estimated 5.7 million Americans.

We're told there are now 28,000 Mainers living with Alzheimer's.

Where did the story come from?

"We believe this is a universal hypothesis of pathogenesis". The study was funded by Cortexyme, which was founded by some of the researchers involved in the study.

'The Science Advances publication sheds light on an unexpected driver of Alzheimer's pathology - the bacterium commonly associated with chronic periodontal disease'.

What kind of research was this?

However, looking at the presence of bacteria in human brain tissue doesn't tell us anything about whether this may have a role in causing the disease. "Human CSF tau also increased over 50% during SD".

What did the research involve?

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The bacteria assaults the brain cells with a hostile protein while also promoting the formation of plaques in brain tissue that are found in Alzheimer's patients.

They also ran an experiment where cultured cells grown in the laboratory were infected with P. gingivalis to see what effect that had on tau protein, a protein that forms tangles in the brains of people with Alzheimer's disease. Moreover, the bacteria eventually developed resistance but did not resist the gingipain blockers.

What were the basic results?

Protein levels are high in people with Lewy body dementia and Huntington's disease; they rise dramatically in people with multiple sclerosis during a flare-up and in football players immediately after a blow to the head.

Alzheimer's is a much-feared condition that, according to the Alzheimer's Association affected over 5.7 million people in the United States alone, in 2018.

How did the researchers interpret the results?

A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer's disease-even before they show signs of confusion and memory loss, according to a new study.

The bug was also shown rapidly to develop resistance against the broad-spectrum antibiotic moxifloxacin, but not to COR388.

"We will have to see the outcome of this ongoing trial before we know more about its potential as a treatment for Alzheimer's".

"Infectious agents have been implicated in the development and progression of Alzheimer's disease before", Dominy said in a statement. People with Parkinson's-like those with Alzheimer's-often have sleep problems.

Through the cognitive testing and brain imaging, NfL levels were shown to be correlated with cognitive decline and brain shrinkage, said Jucker.

Trying to stop Pg buildup, the team designed small molecule inhibitors targeting the toxic enzyme gingipains. If the findings are shown to be correct, this could offer one reason for why 5.7 million Americans are now living with Alzheimer's disease: a figure set to rise to 14 million by 2050.

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